Innate Response Folate, B-12,
& B-6 - 90 Tablets
When crafting all Innate Response Formulas, our mission is to harness
the innate healing response that is within every patient in the time
honored traditions of "vis medicatrix naturae". Following this time
honored tradition we will only use the finest nutrient-rich whole foods
and botanicals that are aligned with these principals.
For every Innate Response Formula it
is our primary goal that each will provide:
- 100% Whole food vitamins and minerals delivered in our
proprietary FoodState food concentrates. Whole food vitamins and
minerals are not in an isolated state, but rather, exist within a
biodynamic FoodState whole food concentrate. FoodState concentrates
not only deliver essential nutrients, but numerous other vital
constituents including bioactive peptides, enzymes, food compounds and
macronutrients that inherently comprise whole food. Each nutrient
is present in a balanced ratio and in a potency equivalent to the
amount found in foods.
- All of the macronutrients and vital food constituents including
bioactive peptides, enzymes, lipids and synergistic compounds that are
inherently present in whole foods are also delivered with each vitamin
and mineral. These constituents have irreplaceable roles as
co-factors in key metabolic bodily functions, and as bio-carriers that
govern nutrient delivery to the cells.
As research continues to validate the importance of these three
vitamins and how inter-related their function is in the body,
supplementation of all three is increasingly more important to sustain
optimal health and metabolic function in the body. Supplementation is
particularly important during pre-conception and pregnancy; in
treatment of megaloblastic anemia and in managing cardiovascular health.
Contraindications/Interactions:
It is suggested, individuals taking anticonvulsant drugs should not
take folic acid supplements as they may increase the risk of seizures.
Folic acid and anticonvulant drugs compete for absorption across the
epithelial cells and the brain cell wall. Medications including
methotrexate, trimethoprim, phenytoin and sulfasalazine interfere with
folate metabolism and may cause functional folate deficiencies.
Recommended Usage: The
recommended dosage is 1-2 servings per day, unless directed otherwise.
Dietary modifications in addition to supplementation are recommended
for long-term results. Additional factors such as a family history of
heart disease, smoking, alcoholism and a sedentary lifestyle may also
influence the risk of elevated homocysteine levels. Suggested to be
taken in conjunction with Cardio Response and/or Cholesterol Response
as well as Innates Prenatal formulas.
Formula Rationale
Although this formula has many clinical applications it was crafted
specifically to help facilitate the bodys innate ability to maintain
healthy homocysteine levels. Several studies have shown that the
supplementation of vitamins folate, B6 and B12 to be very effective in
lowering homocysteine to healthy levels in the bloodstream.
Homocysteine is produced as a normal byproduct of the breakdown of the
amino acid methionine, which is
acquired primarily from eating meat and other proteins.
Elevated homocysteine levels are typically caused from a dietary
imbalance often caused by a diet with excessive animal protein sources
and inadequate levels of B vitamins or by a genetic disorder which
results in an accumulation of homocysteine in the body.
Moderate levels of homocysteine are helpful for the growth and
maintenance of healthy tissue. With a proper nutritional balance,
homocysteine is either converted back into methionine or into other
simple amino acids (cysteine and cystathionine) both of which are
easily flushed from the body via the urine. However, when homocysteine
levels are in excess due to either genetic or dietary factors, it
invades the bloodstream and can cause damage to epithelial cells that
line blood vessels. This damage can cause the build up of fibrous
plaques and excess smooth muscle cells in the vessel walls, creating an
undesirable narrowing of the arteries. These fibrous plaques can also
attract fat and cholesterol found in the bloodstream, causing fatty
deposits and further blockage. Studies have demonstrated that
supplementation of the vitamins folate, B12 and B6 to be effective in
normalizing blood homocysteine levels and thus decrease a risk factor
for heart disease. At least ten percent of coronary heart disease cases
in the US may be caused by hyperhomocysteinaemia.
The inclusion of beet root extract was chosen because of the beneficial
compound betaine it provides. Betaine from dietary sources or from
choline metabolism (dependent on folate, B12 and B6) in the body has
also been shown to be effective in converting homocysteine to
methionine. This conversion can occur without the presence of
methylcobalamin (B12) and therefore is helpful in individuals on a
strict vegetarian diet, excessively consume alcoholic beverages, or
have parasitic infections. Betaine is known to be particularly
effective in managing the genetic disorder homocystinuria that causes
homocysteine levels to accumulate in the body.
Additional Nutritional Applications
In addition, to an increased risk of cardiovascular disease, recent
research has indicated that high homocysteine levels in the body to be
directly associated with neurotoxic effects and an increased risk of
early onset of generalized osteoporosis.
The brain has a high demand for SAMe and choline, both are produced by
methylation reactions involving folate, B6 and B12. These nutrients as
methylation factors and donors are involved in the production of
neurotransmitters and in the maintenance of the myelin sheath.
Therefore, when the body stores of these nutrients and of betaine are
depleted, brain health may also be affected.
A recent study published in the NEMJ found increased circulating levels
of homocysteine levels may be a considerable, independent risk factor
for osteoporotic fractures in older men and women. The researchers
concluded an elevated homocysteine level appears to be a significant,
isolated risk factor for osteoporotic fractures in elderly men and
women.
Supplementation of folate, B6 & B12 is suggested to help manage a
decline in mental health in addition to help maintain long-term bone
health.
Why Folate, B6 & B12
As research continues to determine the effects of increased
homocysteine levels, the importance of supplementing with Folate, B6
& B12 has been researched. Several peer-reviewed studies have
suggested folate supplementation to be effective in lowering
homocysteine levels. Since folates biological actions are directly
linked to the availability of vitamins B6 and B12, it is recommended
that a supplement that delivers all three of these nutrients be
selected for helping to maintain homocysteine levels without disrupting
methylation reactions in the body.
Folate, B6 and B12 work synergistically together, as methylation
factors in a variety of biological reactions in the human body.
Methylation is the biochemical process in which certain molecules
transfer or donate a methyl group (-CH3) to other molecules. This
donation on the one carbon molecule comes from other larger molecules,
called methyl donators. Methylation occurs in every cell of the body
and insufficient levels of any one of these three essential vitamins
will affect many bodily functions including SAMe
production, cell division and blood metabolism.
Whole Food Folate, B6 & B12 Forms
The folate, B6 & B12 vitamins delivered in this formula are 100%
whole food vitamins. As whole food vitamins they are the biological
active form found in the human body and in food. Supplementing with a
whole food form of folate (pteroylmonoglutamate derivatives), is
increasingly important as research continues to challenge the safety of
taking the common synthetic form of folic acid, pteroylmonoglutamatic
acid (PGA). This oxidized compound is the pharmaceutical form of folic
acid and is not normally found as
such in foods or in the human body in significant concentrations, yet
is the form primarily used in supplementation and food fortification.
The consumption of synthetic PGA, is known to interfere with folate
metabolism over a period of years. This is caused by the bodys
inability to fully metabolize the oxidized form, PGA into the active
form, methylfolate which results in an abundance of oxidized PGA
circulating in the body. Unmetabolized levels of PGA have been linked
to interfering with folate dependent enzymes and inhibiting nucleotide
biosynthesis which in turn counteracts the intended benefit of folate
supplementation.
In a recent clinical review of the safety of long term supplementation
and fortification of synthetic PGA, the author strongly suggested that
the long term consequences of supplementing and fortifying food of
synthetic PGA continued to be assessed due to observed biological
consequences in folate metabolism and other enzymatic reactions.
Based on his review of published studies and literature concerning
folic acid, the author stated, we should also be assessing
supplementation with isomer specific native folates that represent the
natural food forms of the vitamins..
Folate, B6 & B12 is FREE of synthetically pure vitamins and
minerals, GMOs, preservatives, binders, pesticides and herbicides.
Ingredients:
Source; FoodState - Vitamin B6,
Folate, Vitamin B12.
Additional Foods & Extracts
- Beet Root (naturally occurring Betaine).
Naturally Occurring Food Constituents
- Bioactive Peptides, Enzymes, Chlorophyll, SOD, Glutathione, Beta
Glucans, Lipoic Acid, Essential Trace Minerals, GABA, Glutamic Acid,
Polysaccharides, CoQ10 and other Compounds.
Other Ingredients - Cellulose,
Rice Bran, Vegetable Lubricant, Guar Gum, Food Glaze.